Congratulations to Tae-Eun and Kotaro for successfully publishing the Rocklin Lab's first paper!! Congrats as well to Cydney and Claire who played important supporting roles. We learned a lot between our initial submission and our revised version, including that some fraction of the designs are dimers and that our original NMR structure was actually a dimer! Thanks to Tae-Eun's persistence and the hard work of Scott Houliston, we actually solved a second NMR structure and collected a second set of HDX data for a monomeric protein. Check it out either at PNAS or see our revised manuscript on bioRxiv.
Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation
Kim*, Tsuboyama* et al. PNAS 2022
bioRxiv Open Access Link