The Rocklin Lab (www.rocklinlab.org) is seeking multiple postdoctoral fellows for experimental and computational projects. We are located in a brand new building on Northwestern’s medical campus in downtown Chicago, in a space dedicated to Northwestern’s Center for Synthetic Biology. Start dates are flexible.
Our group focuses on developing high-throughput technologies for protein biophysics and protein design. We recently developed a new approach to measure protein folding stability for almost a million small domains using cDNA display (Tsuboyama et al. 2023). We also developed a unique approach to measure conformational fluctuations for thousands of protein domains using hydrogen-deuterium exchange mass spectrometry (see poster). We use these datasets to investigate fundamental biophysical questions and to develop predictive models for protein design.
We are very excited to expand these methods to increasingly complex proteins. By improving our technology to assay more complex proteins, we can create more powerful, broadly applicable predictive models. Improving our approaches will also enable us to probe the relationships between stability, conformational fluctuations, and function in natural and designed proteins.
We are seeking interested researchers from any scientific specialization, including biology, chemistry, physics, and computer science. Most researchers in our lab perform both experimental work and computational analysis, but some choose to specialize. We are interested in researchers seeking to develop new experimental technology, apply our technologies in new ways, and develop improved predictive models. We are especially interested in expertise in RNA biochemistry/mRNA display, proteomics, hydrogen exchange mass spectrometry, protein biophysics, and machine learning, but please apply if you are interested and bring a different specialization.
Why join the Rocklin Lab?
We are a multidisciplinary and collaborative group in a fantastic environment. Our researchers are integrated into several larger communities that expand their scientific reach, including Northwestern’s Center for Synthetic Biology, Northwestern’s proteomics community, and the international Rosetta Commons protein modeling and design community. We work to create an environment that prioritizes mentoring and collaboration and I am excited to talk about this with candidates.
Please visit rocklinlab.org or email firstname.lastname@example.org to learn more.
To apply, please email me your CV and a cover letter describing your interests.