- Keep your eyes on the prize, by Ron Vale
- A Critique of the Hypothesis, and a Defense of the Question, as a Framework for Experimentation, by David Glass. A good explanation of why model-building, not hypothesis-testing, is the most productive form of science
Two papers on choosing projects. Together, these papers offer an incredibly valuable perspective on how to do science.
- How to choose a good scientific problem, by Uri Alon
- Problem choice and decision trees in science and engineering, by Michael Fischbach
- A wake-up call: How failing a PhD led to a strategy for a successful scientific career, by Bruce Alberts. I love this piece because it emphasizes the value of good scientific questions and practical approaches rather than specific hypotheses.
- How to do great work, by Paul Graham. This is targeted at a broad audience of young people. I think this contains tons of great advice for young scientists.
- You and Your Research (1986), by Richard Hamming. This is a bit dated and somewhat intentionally provocative, but I think there's lots of very sound advice in here about how to do really important research. I don't devote my entire life to research and I don't expect my lab members to devote their entire lives either, but I think this is great to read and learn from.
- Understanding Academic Medical Centers: Simone's Maxims, by Joseph Simone. An interesting perspective on academic medical centers. I am too new to say whether I agree or not ;)