ROCKLIN LAB @ NORTHWESTERN CHICAGO
  • Research
  • People
  • Join
  • Papers
  • Resources
  • News
  • Contact

Two years!

4/13/2021

0 Comments

 
Hi, I want to get in the habit of sharing lab news more, so let me do a big dump of lab news from the lab's second year. Certainly the past year was a painful year for the world and wreaked havoc on the lives of our lab members to varying degrees. But I think we can be proud of the ways we tried to stay connected over the past year and the progress people were able to make despite the pandemic. So, here's a summary of some of the big achievements of the lab's second year-

Lots of new people joined the lab!

Cydney Martell joined the lab as our 2nd PhD student from the DGP program. Will Corcoran also joined the lab as a joint student with Josh Leonard's lab (Will was previously just advised by Josh).

Jane Thibeault joined the lab as our third postdoctoral fellow, soon followed by Állan Ferrari who just started as our fourth fellow. Both Jane and Állan have backgrounds in proteomics and computation.

Radhika Dalal joined the lab as a Rosetta Commons Postbaccalaureate Fellow!

We won some awards!

The lab was awarded our first external grant - a prestigious NIH New Innovator award. This award will support our work to develop a high-throughput hydrogen-deuterium exchange approach to study protein energy landscapes.

Kotaro Tsuboyama started his fellowship as a Long-Term Fellow of the Human Frontiers Science Program!

Állan Ferrari was awarded a BEPE Fellowship!

Cydney Martell was awarded a competitive spot in Northwestern's Center for Life Processes Training Program!

Will Corcoran was awarded a competitive spot in Northwestern's Biotechnology Training Program!

We hosted summer students!

Jordan Gewing-Mullins and Nahtalee Lomeli worked with us remotely over Summer 2020.

Some of us moved on...

Our first lab member Claire Phoumyvong moved on to join Northwestern's DGP Ph.D. program. She is now back rotating in our lab though :)

One of my goals this year is to update the website more frequently, so hopefully there will be more news soon!
0 Comments

We are hiring postdocs!

8/2/2020

2 Comments

 
Postdoctoral positions in high-throughput protein biophysics,
machine learning, and design

 
The Rocklin Lab (www.rocklinlab.org) is seeking multiple postdoctoral fellows for experimental and computational projects. We are located in a brand new building on Northwestern’s medical campus in downtown Chicago, in a space dedicated to Northwestern’s Center for Synthetic Biology. Start dates are flexible.
 
About us
Our group focuses on applying high-throughput technologies to protein biophysics and protein design. We construct libraries of thousands of proteins (de novo designed or naturally occurring), assay their properties using multiplexed methods, and analyze these datasets to understand how protein phenotypes arise from protein sequence and structure. These insights enable us to design new proteins with unique properties. For examples of this approach, see Rocklin et al. 2017 and Chevalier et al. 2017.
 
One of our exciting new experimental tools is an approach to measure conformational fluctuations for thousands of proteins in parallel using hydrogen exchange mass spectrometry (see poster). We are using this unprecedented large data to examine:
 
  • How do protein sequence and structure determine stability and fluctuations?
  • How do point mutants alter conformational dynamics, and can we predict this?
  • Can our hydrogen exchange data be integrated with other, even larger-scale data (“transfer learning”) to build accurate deep learning models of stability and dynamics? 
  • Can we use our large-scale data to improve physical models of protein stability and fluctuations (MD force fields, Rosetta), and model structures of excited states?
 
Position description
We are looking for interested researchers from any scientific specialization, including biology, chemistry, physics, and computer science. We are especially interested in expertise in hydrogen exchange mass spectrometry, protein biophysics, and machine learning, but please apply if you are interested and bring a different specialization. Computational research will be entirely remote during the Covid-19 pandemic.
 
Why join the Rocklin Lab?
We are building a multidisciplinary and collaborative group in a fantastic environment. Our researchers are integrated into several larger communities that expand their scientific reach, including Northwestern’s synthetic biology community (https://syntheticbiology.northwestern.edu), Northwestern’s proteomics community (http://proteomics.northwestern.edu), and the international Rosetta protein modeling and design community (https://www.rosettacommons.org). 
 
Please visit rocklinlab.org or email [email protected] to learn more.
To apply, please email me your CV and a cover letter describing your interests.
​
rocklin_lab_postdoc_ad_july_2020.pdf
File Size: 251 kb
File Type: pdf
Download File

2 Comments

We've moved buildings!

10/4/2019

0 Comments

 
Last week we officially moved into our space in the brand new Simpson Querrey building! We're very excited to share the wet lab space along with our Center for Synthetic Biology buddies in the Prindle Lab.

Thank you so much to Claire, Wes, and rotation students Katiannah and Aishwarya for all your work to make the move go smoothly!

It's beautiful here!
Picture
Picture
Picture
0 Comments

Why join the Rocklin Lab?

9/11/2019

0 Comments

 
Here's a talk I gave to the incoming DGP students about why they should rotate in our lab. We have at least six rotating students in 2019-2020!
rocklin_lab_dgp_introduction.pptx
File Size: 22155 kb
File Type: pptx
Download File

0 Comments

We are open!!

3/15/2019

0 Comments

 
Well, actually we opened on Monday. Busy week!
0 Comments

Let's meet at a conference!

2/22/2019

0 Comments

 
I (Gabriel) am coming to/presenting at a number of upcoming conferences, and I'd love meet people interested in joining the lab. In the near future-
  • Biophysical Society (Mar 2-4, Baltimore) - Talk Sunday Mar 3 11:15am in the "Proteins: Exploring Sequence Space via Computation and Experiment" Symposium
  • American Chemical Society (Mar 31-April 3, Orlando) - Poster Tues April 2 6pm-8pm in the Biomedical Technologies poster session, West Hall C
  • Protein Engineering Summit (PEGS) Boston (April 10-12, Boston) - Talk Thurs April 11 9:05am in the "Emerging Technologies in Antibody Engineering" session
  • Hydrogen-Deuterium Exchange Mass Spectrometry (HDXMS) 2019 (May 21-24, Banff)
  • Proteins Gordon Research Conference (June 16-21, Holderness)

Hope to see you there, e-mail me if you're interested in talking!
0 Comments

We're hiring!

11/14/2018

0 Comments

 
We are looking for undergraduate researchers, research technicians, graduate student researchers, and postdoctoral fellows. Our work is interdisciplinary, and we are looking for people with many different backgrounds including biology, chemistry, physics, and computer science.

​Undergraduate research positions: Please send me a brief description of your previous experience (OK if this is primarily classes) and an explanation of why you're interested in working with us.

Research technician positions: Please send me your resume or CV, along with an explanation of what you're looking for out of your experience.

Ph.D. student positions: Apply to the Northwestern IBiS or DGP. If you're already here, please get in touch and let's talk about your interests!

Postdoctoral fellow positions: Please send me your CV, a cover letter explaining your goals and why you're interested in the lab, and names of three references.

Contact me.
0 Comments
Forward>>

    Gabriel Rocklin

    Assistant Professor
    Northwestern Dept. of Pharmacology
    ​Center for Synthetic Biology

    Archives

    November 2023
    September 2023
    August 2023
    July 2023
    October 2022
    August 2022
    March 2022
    February 2022
    July 2021
    April 2021
    August 2020
    October 2019
    September 2019
    March 2019
    February 2019
    November 2018

    Categories

    All

    RSS Feed

  • Research
  • People
  • Join
  • Papers
  • Resources
  • News
  • Contact